Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)
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Carbon-11 and Fluorine-18 Labeled Amino Acid Tracers for Positron Emission Tomography Imaging of Tumors
Tumor cells have an increased nutritional demand for amino acids (AAs) to satisfy their rapid proliferation. Positron-emitting nuclide labeled AAs are interesting probes and are of great importance for imaging tumors using positron emission tomography (PET). Carbon-11 and fluorine-18 labeled AAs include the [1-11C] AAs, labeling alpha-C- AAs, the branched-chain of AAs and N-substituted carbon-1...
متن کاملEvaluating atypical dementia syndromes using positron emission tomography with carbon 11 labeled Pittsburgh Compound B.
CONTEXT A progressive decline in episodic memory affecting activities of daily living is the usual clinical presentation of Alzheimer disease. However, patients presenting with atypical or focal clinical symptoms such as language or visuospatial dysfunction often pose a diagnostic challenge. OBJECTIVE To explore the presence and topography of beta amyloid (Abeta) as measured by carbon 11-labe...
متن کاملCarbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
BACKGROUND Alzheimer disease (AD) is defined neuropathologically by the presence of neurofibrillary tangles and plaques associated with tau and beta-amyloid protein deposition. The colocalization of microglia and beta-amyloid plaques has been widely reported in pathological examination of AD and suggests that neuroinflammation may play a role in pathogenesis and/or progression. Because postmort...
متن کاملIn Vivo Tissue Pharmacokinetics of Carbon-11-Labeled Clozapine in Healthy Volunteers: A Positron Emission Tomography Study
We investigated clozapine (CLZ) tissue pharmacokinetics in vivo by using carbon-11-labeled CLZ ((11)C-CLZ) and positron emission tomography (PET). Eight healthy volunteers underwent (11)C-CLZ studies wherein computed tomography image acquisition was followed by PET scans (whole-body, four; brain, four). After bolus intravenous (11)C-CLZ injection, PET images were acquired at various timepoints ...
متن کاملThe effect of fasting on Positron Emission Tomography (PET) imaging
As a nuclear approach, Positron Emission Tomography (PET) is a functional imaging technique which is based on the detection of gamma ray pairs emitted by a positron-emitting radionuclide. There are certain limitations to this technique such as normal tissue uptake. Therefore, it has been recommended that patients prepare before scanning. Fasting for a short while before PET imaging is an exampl...
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ژورنال
عنوان ژورنال: Nuclear Medicine and Biology
سال: 2007
ISSN: 0969-8051
DOI: 10.1016/j.nucmedbio.2006.11.004